Spatial Hemodynamics, the Endothelium, and Focal Atherogenesis
نویسندگان
چکیده
منابع مشابه
Spatial hemodynamics, the endothelium, and focal atherogenesis: a cell cycle link?
The characteristics of arterial flow and the hemodynamic forces associated with them have important effects upon endothelial biology1 that have long been implicated in the nonrandom distribution of atherosclerotic lesions.2 At branches, curvatures, and bifurcations of large elastic and muscular distributing arteries, separations of the flow streamlines create regions of disturbance that correla...
متن کاملCommentary Vascular Endothelium, Hemodynamic Forces, and Atherogenesis
Intimal lipid accumulation, hyperplasia, and scarring are stigmata of atherosclerotic vascular disease, whose major complications—myocardial and cerebral ischemia and infarction—continue to be major health problems in developed nations. This insidiously progressive disease typically spans decades, but can reach a clinical horizon in a matter of minutes due to critical changes in a given atheros...
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Spatial and temporal dynamics of the endothelium.
The endothelium is a highly metabolically active organ that is involved in many physiological processes, including the control of vasomotor tone, barrier function, leukocyte adhesion and trafficking, inflammation, and hemostasis. Endothelial cell phenotypes are differentially regulated in space and time. Endothelial cell heterogeneity has important implications for developing strategies in basi...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2000
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.86.2.114